Custom synthesis

AppliChem was founded in 1992 and started business by synthesizing special chemicals for a few customers and offering chemical technical services for many different applications.
Since then our company has become a reliable partner of the pharmaceutical industry for the outsourcing of key molecules which becomes necessary when internal resources are unavailable or over-stretched.
There is ongoing co-operation with scientific institutes, the chemical industry and research departments of the pharmaceutical and the diagnostic industry.

Single-step and multi-step synthesis

Many of our standard products have been developed according to our customers‘ demand and ideas. They have been integrated into our continuously-growing product range of speciality chemicals and biochemicals. A lot of products used in diagnostics, biotechnical productions and chemical manufacturing processes are listed in our biochemicals catalog.

Building blocks for combinatorial chemistry

AppliChem has been using the wide range of established synthesis methods to create building blocks for combinatorial chemistry for the last two years. The range of highly-reactive compounds is growing day by day. For further information, please contact our chemists.

Synthesis elaboration from concept to start-up

Due to the small size of our company we are very flexible, having short lines of communication and a strong focus on our customer‘s demand. So we are in the position to develop new products in a short time. Our experience with chemical techniques, practised continuously with the existing products, is of added value to our customers.
We are in a position of having well-equipped laboratories, where we can carry out most of the standard organic and inorganic synthesis methods in quantities of some milligrams to multi kilograms.

The preparation of chemicals is always performed with utmost care under the guidelines of our quality control. The products are controlled by analytical methods like HPLC, TLC and NMR as well as by chemical analytical methods. This enables us to ensure the highest purity of the products and to fulfill the specifications of our customers.
The attached list of chemical processes will show you the wide range of reactions that we are able to apply to the synthesis of our products.
Please do not hesitate to contact us for quotations on our products. Enquiries will always be treated confidentially.

Dr. Udo Heim
u.heim@applichem.c3d6gecom

 

Summary of the most important procedures that we can carry out in our laboratories:

  • Acetylations by acetyl chloride and acetic acid anhydride
  • Alkylations by alkyl halides and alkyl sulfates
  • Carboxylic ester condensation
  • Catalytic hydrogenations up to 3 bar (1 L Autoclave)
  • Catalytic reductions by hydrogen
  • Chlorinations by thionyl chloride
  • Cleavage of ethers by BBr3
  • Diazotizations and Sandmeyer reactions
  • Eschweiler-Clarke methylations
  • Esterifications and saponifications
  • Fluorinations by different fluorinating reagents except elementary fluorine
  • Formations of ethers by different methods (Williamson, Mitsunobu)
  • Friedel-Crafts alkylations and acylations
  • Gabriel synthesis
  • Haloform reactions
  • Halogenations and halogen exchange reactions
  • Hydroborations by 9-BBN, borane-THF and borane-amine complexes
  • Hydroxymethylations by formaldehyde
  • Isolations of natural stuffs
  • Ketone and aldehyde condensation reactions
  • Knoevenagel condensations
  • Michael reactions
  • Nitrations of aromatic rings by nitrating acid mixtures or nitric acid
  • Nucleophilic substitution reactions
  • Oxidations by peracids, H2O2, nitric acid and others
  • Perkin reaction
  • Purifications of chemicals for special applications
  • Reactions at low temperatures (up to –78°C)
  • Reactions using hydrogen chloride
  • Reactions in an inert gas atmosphere
  • Reductions by metal hydrides
  • Reductions by sodium metal
  • Reductive aminations
  • Seperation of enantiomers
  • Silylations
  • Sulfonations and chlorosulfonations
  • Synthesis of deuterated compounds
  • Synthesis of carboxylic acid chlorides by PCl5, PCl3 or SOCl2
  • Synthesis elaboration for new compounds and known compounds
  • Synthesis of heterocyclic compounds by various methods
  • Synthesis of indole derivatives
  • Synthesis of protected and unnatural amino acids
  • Synthesis of metal salts of inorganic or organic acids
  • Synthesis using organometallic compounds (Grignard- and organolithium compounds)
  • Tailor made solutions and mixtures
  • Vilsmeier reactions
  • Wittig- and Wittig-Horner reactions
  • Wolff-Kishner reductions
  • and many many more ......